Sailgene Technology

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Pore-c

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Introduction
Applications
Highlights
Publications

Introduction

Conformation capture (3C) with Nanopore long-read sequencing, enabling the detection of multi-locus interactions andassociated DNA methylation pattems within genomes. Its streamlined workflow eliminates theneed for biotin labeling or PCR amplification, while effectively capturing complex GC-rich andrepetitive regions-all while preserving epigenetic information.Pore-C offers deeper insights into chromatin interactions, facilitates the distinction of allelicgenes, and significantly enhances the quality of genome assemblies in both animals and plants.It also helps correct misassemblies and supports advanced research into the three-dimensionalspatial organization of the genome and multiplex chromatin interactions.

Applications

3D genome research

Improving assembly contiguity

Efficient Haplotype-resolved Assembly

DNA methylation modification and chromosome structure relationship research

Highlights

Capable of detecting a greater number ofhigher-order interactions

The absence of an amplification step that isrequired in other chromatin conformationcapture methods

Bisulfite conversion (as is required in Methyl-HiC) is not required when detecting DNAmethylation.

Upgraded flow cells and basecalling modelsachieve Super Accuracy Reads with amedian Q score of up to Q28.

Pore-C improves interaction data in complex regions,helping to locate complex contigs on chromosomes

Publications

Year	Journal	Impact Factor	Title
2024	Horticulture Research	8.5	A telomere-to-telomere gap-free reference genome assembly of avocado provides useful resources for
2022	Plant Biotechnology Journa	6.3	Multi-omics mapping of chromatin interaction resolves the fine hierarchy of 3D genome in allotetraploid cotton

Keyword:

Pore-c

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SMAC-seq

If you are interested in our long-read sequencing services or potential collaboration, please contact us. Our team is ready to support your research with tailored solutions. We also welcome feedback from users to help us improve our services.

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WhatsApp：1-(617)-223-7544

Tel：1-(617)-223-7544

E-mail：service@sailgene.com

Add: One Innovation Drive, Suite B3-406, Worcester, MA 01605, USA